A Study Comparing Two Buffered Numbing Injections Used During Tooth Extraction in Children

Buffered Articaine Versus Buffered Lignocaine in Dental Extractions: A Double Blind Split Mouth Crossover Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/102927

Enrollment

Registered

2026-02-03

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues

Interventions

Intervention1: Buffered Articaine: Children aged 4 7 years undergoing bilateral extraction of primary first molars will receive buffered articaine for one extraction and buffered lignocaine for the co

Eligibility

Inclusion criteria

Inclusion criteria: 1.Children aged 4 to 7 years requiring bilateral extraction of primary first molars. 2.Children with ASA Physical Status I or II. 3.Children indicated for extraction under local anesthesia only. 4.Children who are cooperative, allowing dental treatment under local anesthesia. 5.Written informed consent obtained from the parent or legal guardian. 6.Children able to communicate pain or discomfort using age-appropriate pain assessment scales.

Exclusion criteria

Exclusion criteria: 1.Children with known allergy or hypersensitivity to local anesthetics, epinephrine, or buffering agents. 2.Children with systemic illness or medical conditions contraindicating the use of local anesthesia or vasoconstrictors. 3.Children with special health care needs, developmental delay, or neurological disorders affecting pain assessment. 4.Children presenting with acute infection, abscess, cellulitis, or swelling at the extraction site. 5.Children who have received analgesics, sedatives, or local anesthesia within 24 hours prior to the procedure. 6.Children with bleeding disorders or receiving anticoagulant therapy. 7.Children who are uncooperative and unsuitable for treatment under local anesthesia. 8.Children whose parent or legal guardian refuses consent or withdraws consent at any stage of the study.

Design outcomes

Primary

Measure	Time frame
1.Onset of local anaesthesia, measured as the time taken to achieve pulpal anaesthesia. 2.Pain experienced by the child during tooth extraction, assessed using an age-appropriate pain assessment scale.Timepoint: 1.Time taken for onset of anaesthesia- at 30seconds, 60seconds, 90seconds, 120seconds, 150seconds, 180seconds. 2.Pain experienced by the child during extraction- measured immediately post treatment using age appropriate pain assessment scale.	—

Measure

Time frame

1.Onset of local anaesthesia, measured as the time taken to achieve pulpal anaesthesia. 2.Pain experienced by the child during tooth extraction, assessed using an age-appropriate pain assessment scale.Timepoint: 1.Time taken for onset of anaesthesia- at 30seconds, 60seconds, 90seconds, 120seconds, 150seconds, 180seconds. 2.Pain experienced by the child during extraction- measured immediately post treatment using age appropriate pain assessment scale.

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Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactEkambareswaran K

Saveetha Dental College and Hospitals

drekapedo@gmail.com9677246945

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026