Comparison of two doxycycline gels used along with cleaning of teeth and gums in people with severe gum disease

Comparative evaluation of a Novel Doxycycline gel and 10 percent Doxycycline Hyclate Gel as an adjunct to Scaling and Root Planing in Stage III Periodontitis A Randomized Controlled Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/102906

Enrollment

Registered

2026-02-03

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Novel doxycycline gel: novel doycycline gel is formulated using proniosomes as delivery vescicles which improves substantivity compared to commercially available will be adiministered u

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients with stage two and three Periodontitis. Non-smokers. Presence of more than one site with probing pocket depth four to six mm. No periodontal treatment in the past six months.

Exclusion criteria

Exclusion criteria: Systemic diseases Pregnancy or lactation Antimicrobial therapy less than three months. History of allergy and alcohol or drug abuse and smoking

Design outcomes

Primary

Measure	Time frame
PPD and RALTimepoint: 1 3 and 6 months	—

Secondary

Measure	Time frame
GI PI and patient comfortTimepoint: 1 3 and 6 months	—

Countries

India

Contacts

Public ContactDr Vrushali Lathiya

drvrushalilathiya@gmail.com09561100520

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026