Effect of yoga combined with usual rehabilitation exercises in improving exercise capacity in patients of COPD

Efficacy of Pulmonary Rehabilitation Augmented by Yoga on Exercise Capacity and Quality of Life in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease: A Randomised Controlled Trial - PRAYOGIC

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/102813

Enrollment

116

Registered

2026-02-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified Health Condition 2: J439- Emphysema, unspecified Health Condition 3: J42- Unspecified chronic bronchitis

Interventions

Intervention1: Combined Yoga plus pulmonary rehabilitation: Patients will visit AIIMS twice a week in the first week, during which they will be taught the basics of yoga and pulmonary rehabilitation e

Eligibility

Inclusion criteria

Inclusion criteria: Moderate to severe COPD (FEV1 less than 50% predicted) Controlled symptoms for the last 7 days, without systemic steroids or antibiotics Willing to participate and attend in-hospital pulmonary rehabilitation for the next 12 weeks Ready to give written informed consent

Exclusion criteria

Exclusion criteria: Patients requiring hospitalisation (till stabilization/recovery) (shall be reassessed for inclusion after discharge) On treatment for active respiratory infections (e.g., tuberculosis, chronic pulmonary aspergillosis etc.) Presence of severe comorbidities such as hematological or solid organ malignancy, symptomatic cardiovascular disease, musculoskeletal or neurological disease that might affect ambulation or exercise training Ccognitive dysfunction, mental disorder or abnormal behaviors Inability to follow up as per protocol Participation in a pulmonary rehabilitation programme in the past 12 months Currently practicing yoga based rehabilitation Participating in another interventional trial Patients with a life expectancy of less than four weeks

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of yoga alone, pulmonary rehabilitation alone, and the combination of yoga and pulmonary rehabilitation in improving exercise capacity, as measured by the 6-minute walk test in patients with moderate to severe chronic obstructive pulmonary diseaseTimepoint: To compare the efficacy of yoga alone, pulmonary rehabilitation alone, and the combination of yoga and pulmonary rehabilitation in improving exercise capacity, as measured by the 6-minute walk test in patients with moderate to severe chronic obstructive pulmonary disease	—

Measure

Time frame

To compare the efficacy of yoga alone, pulmonary rehabilitation alone, and the combination of yoga and pulmonary rehabilitation in improving exercise capacity, as measured by the 6-minute walk test in patients with moderate to severe chronic obstructive pulmonary diseaseTimepoint: To compare the efficacy of yoga alone, pulmonary rehabilitation alone, and the combination of yoga and pulmonary rehabilitation in improving exercise capacity, as measured by the 6-minute walk test in patients with moderate to severe chronic obstructive pulmonary disease

—

Secondary

Measure	Time frame
Maximal exercise capacity (VO2 max) COPD Assessment Test (CAT) Lung function (FEV1) Forced oscillometry testing parameters (R5, R20, R5-R20, Ax) Body plethysmography (Total lung capacity and RV/TLC) Time to next exacerbation (months) Body composition (using body impedance analysis) Inflammatory biomarkers (CRP, SAA, IL-6, IL10, YKL-40, 8-Isoprostane and FENO) Feasibility and utility of telemonitored parameters (heart rate, daytime activity, daily step counts, sleep quality and nocturnal saturation) using personalised monitoring (smartwatch)Timepoint: 12 weeks	—

Measure

Time frame

Maximal exercise capacity (VO2 max) COPD Assessment Test (CAT) Lung function (FEV1) Forced oscillometry testing parameters (R5, R20, R5-R20, Ax) Body plethysmography (Total lung capacity and RV/TLC) Time to next exacerbation (months) Body composition (using body impedance analysis) Inflammatory biomarkers (CRP, SAA, IL-6, IL10, YKL-40, 8-Isoprostane and FENO) Feasibility and utility of telemonitored parameters (heart rate, daytime activity, daily step counts, sleep quality and nocturnal saturation) using personalised monitoring (smartwatch)Timepoint: 12 weeks

—

Countries

India

Contacts

Public ContactPawan Tiwari

All India Institute of Medical Sciences, New Delhi

pavan14281@gmail.com01126593676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026