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To Compare Nebulized Ropivacaine (0.75%) With Nebulized Dexmedetomidine on the hemodynamic response to intubation in patients undergoing General anesthesia.

A RANDOMIZED CLINICAL TRIAL TO COMPARE NEBULIZED ROPIVACAINE (0.75 percent) WITH NEBULIZED DEXMEDETOMIDINE ON THE HEMODYNAMIC RESPONSE TO INTUBATION IN PATIENTS UNDERGOING GENERAL ANESTHESIA - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/02/102792
Enrollment
128
Registered
2026-02-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R09- Symptoms and signs involving the circulatory and respiratory systems

Interventions

Intervention1: During the nebulization process: The oversees nebulization and whole procedure and can intervene if any side effects such as bradycardia , coughing and increased sedation occurs. If suc

Sponsors

Dr Archana
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: It includes patients with ASA grade 1 and 2 patients with Mallampati grade 1 and 2 elective surgeries with duration of less than 120 mins

Exclusion criteria

Exclusion criteria: it excludes hemodynamically unstable patients patients with history of sore throat or upper respiratory tract infection patients with allergy to local anesthetics and dexmedetomidine patients with history of cardiac, liver and renal disorders patients with difficult airway where a laryngoscopy is expected to take more than 15 seconds

Design outcomes

Primary

MeasureTime frame
To compare and evaluate the effectiveness of nebulized Ropivacaine (0.75%) and nebulized Dexmedetomidine in attenuating the hemodynamic response during laryngoscopy and endotracheal intubationTimepoint: THE HEMODYNAMIC RESPONSE MEASURED T0- baseline before nebulization T1- immediately after nebulization T2- before tracheal intubation T3- immediately after tracheal intubation T4 - 5 minutes after tracheal intubation T5- at the closure of the skin incision T6- immediately after tracheal extubation T7-5 minutes after tracheal extubation

Secondary

MeasureTime frame
TO ASSESS 1.THE HEMODYNAMIC PARAMETERS AT EXTUBATION 2. COUGH RESPONSE AT EXTUBATION 3. INCIDENCE RATE OF POST OPERATIVE SORE THROAT AFTER EXTUBATIONTimepoint: 1.Immediately & 5minutes after extubation 2. COUGH RESPONSE at 0, 5 AND 30 MINUTES 3. POSTOPERATIVE SORE THROAT at - 0,2,4,6,12 AND 24 HOURS

Countries

India

Contacts

Public ContactDr. Vidya Patil

SHRI B.M. PATIL MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER

Vidyapatila@gmail.com9448131260

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026