Health Condition 1: F329- Major depressive disorder, singleepisode, unspecified
Conditions
Interventions
Intervention1: Active tDCS: Use of HD-tDCS device by Soterix medical Inc. To give active current of low intensity of 2 mA with anode placed over F3 and cathode over F4 for 30 minutes for 10 days(2 wee
Sponsors
VMMC and Safdarjung Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patient of Age range- 18-65 years newly Diagnosed with Major Depressive Disorder As per DSM-V TR Currently on SSRI mono-therapy willing to provide informed consent.
Exclusion criteria
Exclusion criteria: Metal implant in head including intracranial electrodes, surgical clips, shrapnel or Implanted pacemaker in heart. History of Head injury resulting in loss of consciousness, history of Epilepsy or neurological disorders Concurrent use of other neuromodulation therapies like ECT, TMS Substance use disorder except nicotine and caffeine Pregnancy and lactation Patient with any other psychiatric comorbidity Patient with any medical comorbidity that are uncontrolled even on medication Unable to read and write Hindi / English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in depressive symptom severity, as measured by the Hamilton Depression Rating Scale (HDRS-17)Timepoint: at baseline and at end of 2 week tDCS session. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in anxiety symptoms, measured using the Hamilton Anxiety Rating Scale (HAM-A).Timepoint: Baseline to day 14 post intervention;Change in suicidal ideation, assessed by the Columbia Suicide Severity Rating Scale (C-SSR), Hindi version.Timepoint: Baseline at pre intervention to Day 14;Change in cognitive function, as measured by the Addenbrooke s Cognitive Examination III Hindi version (ACE-III Hindi).Timepoint: Baseline at pre intervention to Day 14 | — |
Countries
India
Contacts
Public ContactDr Brinda Shree
Vardhaman Mahavir medical college and Safdarjung Hospital
Outcome results
None listed