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Effect of Split Dose versus Single Dose Spinal Anaesthesia on Blood Pressure Stability in Patients Undergoing Lower Limb Orthopaedic Surgery

A comparison of the effect of fractionated dose versus bolus dose injection in spinal anesthesia for patient undergoing lower limb orthopaedic surgery . - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/102774
Enrollment
80
Registered
2026-02-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Fractionated Dose injection of Hyperbaric bupivacaine and fentanyl in spinal anesthesia.: In the operation theatre, all patients will receive IV fluid preloading with 10 ml/kg prior to

Sponsors

Mahatma Gandhi medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient undergoing elective lower limb orthopaedic surgery under spinal anaesthesia 2. age 18-65 years 3. all genders 4. American Society of anaesthesiologists (ASA) grade I and II

Exclusion criteria

Exclusion criteria: 1. Contraindication of spinal anaesthesia 2. History of drug allergy 3. Coagulopathy 4. Local site infection 5. Spine deformities 6. Severely altered mental status 7. Increased intra cranial pressure 8. Pregnant and lactating females

Design outcomes

Primary

MeasureTime frame
To compare the haemodynamic changes in both the group . systolic blood pressure,mean arterial pressure,heart rateTimepoint: The effect will be assessed for 2.5 hours post procedure.—

Secondary

MeasureTime frame
To compare the effect of analgesia in both the group .Timepoint: The effect will be assessed for 4 hours post operative.—

Countries

India

Contacts

Public ContactDrKalpana Verma

Mahatma Gandhi medical college and hospital

kalpana2007.kv@gmail.com7727886029

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026