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Comparison of Different Doses of Remifentanil on Heart Rate and Blood Pressure Changes During Anesthesia

Effect of Different Doses of Remifentanil on Hemodynamic Response after Endotracheal Intubation in a Tertiary Care Hospital: An Open Label Study - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/102760
Enrollment
80
Registered
2026-02-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj Remifentanil + Inj Nalbuphine: Remifentanil 1.0mcg/kg + Nalbuphine 0.1mg/kg Intervention2: Inj Remifentanil + Inj Nalbuphine: Remifentanil 1.5mcg/kg + Nalbuphine 0.1mg/kg Intervent

Sponsors

All India Institute of Medical Sciences, Deoghar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Elective surgeries under general anaesthesia 2. Duration of surgery 45 minutes to 2 hours 3. ASA physical status 1 and 2

Exclusion criteria

Exclusion criteria: 1. Uncontrolled hypertension 2. Severe hypotension 3. Emergency Surgery 4. Negative consent 5. Difficult airway

Design outcomes

Primary

MeasureTime frame
To compare the changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) following laryngoscopy and endotracheal intubation among different doses of remifentanil.Timepoint: 1. Baseline (after preoxygenation) 2. 1 min after endotracheal intubation 3. 5 min after endotracheal intubation 4. 10 min after endotracheal intubation—

Secondary

MeasureTime frame
To assess the incidence of side effects associated with different doses of remifentanil.Timepoint: 0-2 hours, 2-6 hours, 6-24 hours—

Countries

India

Contacts

Public ContactHarsh Gupta

All India Institute of Medical Sciences, Deoghar

ripon85@gmail.com9914789458

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026