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A study to understand how blood flow and heart function affect recovery in patients with severe infection in the emergency department.

PREDICT (Perfusion Restriction Evaluation with Doppler Indices, Cardiac output and Thermography): A study of Point of Care arterial doppler indices, Microcirculatory and Macro circulatory parameters and their association with clinical outcomes in patients with sepsis presenting to the Emergency Medicine department. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/02/102756
Enrollment
85
Registered
2026-02-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I798- Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Dr Mithun Kiran
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients more than 18 years presenting to ED with suspected sepsis (fever or source of infection and SIRS criteria) requiring ICU or HDU admissions.

Exclusion criteria

Exclusion criteria: Patients in septic shock requiring more than 1 vasopressor or high dose vasopressor (Norepinephrine or Epinephrine more than 0.3 mcg per kg per min, Dopamine more than 15mcg per kg per min) at the time of recruitment. Patients with ongoing major haemorrhage (GI bleed, intracranial bleed, massive haemoptysis, obstetric haemorrhage, trauma related bleeding.) Bilateral femoral site vascular access. Patients who are pregnant. Suspected sepsis patients with an established alternate diagnosis during the course of stay in the hospital. Patients with known peripheral vascular disease (PVD) will be excluded, as it may confound Doppler and thermography assessments of peripheral perfusion.

Design outcomes

Primary

MeasureTime frame
To study the association of point of care femoral, dorsalis pedis, aortic doppler indices and microcirculatory parameters (capillary refill time, plethysmography perfusion index, lactate and IR thermography mottling indices) along with macro circulatory parameters (heart rate, blood pressure, left ventricular outflow tract area, velocity-time integral, stroke volume) with 24 hours and 72 hours clinical outcomes in patients with suspected sepsis presenting to the Emergency Medicine Department.Timepoint: Time of presentation, 24 hours, 72 hours, 1 week.—

Secondary

MeasureTime frame
To study the association of point of care femoral, dorsalis pedis, aortic doppler indices & microcirculatory parameters (capillary refill time, plethysmography perfusion index, lactate, & IR thermography mottling indices) with survival to discharge & length of ICU stay of the above study subjects.Timepoint: At the time of presentation, 24 hours, 72 hours, one week.—

Countries

India

Contacts

Public ContactDr Mithun Kiran

Kasturba Medical College, Manipal

jayaraj.mb@manipal.edu9895063580

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026