FindTrial
Sign In

A study on the use of melatonin film to improve healing and reduce pain following gum surgery.

Evaluation of the effect of 3mg Melatonin Film along with open flap debridement on wound healing and pain perception in patients with Stage II Grade B periodontitis: A Placebo-Controlled Randomized Clinical Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/102708
Enrollment
40
Registered
2026-02-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: 3 mg Melatonin: 3 mg melatonin film will be placed inside the flap after debridement and then sutured back for improved wound healing and pain perception Control Intervention1: placebo

Sponsors

Shruti Bendke
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients in age range of 18 50yrs. 2.Subject should have at least 20 natural permanent teeth. 3.Patient with Periodontitis Stage II Grade B

Exclusion criteria

Exclusion criteria: 1.Smokers and tobacco chewers. 2.Patients using orthodontic or prosthodontic appliances either fixed or removable. 3.Patients with systemic diseases, pregnancy, or lactating woman. 4.Patients with previously reported allergy to drug. v. Patients with history of insomnia and under medication

Design outcomes

Primary

MeasureTime frame
1.To evaluate wound healing using Wound Healing Index (WHI) after placement of 3mg melatonin film along with open flap debridement. 2. To evaluate wound healing using Wound Healing Index (WHI) after placement placebo film along with open flap debridement. 3. To compare wound healing in patients with Stage II Grade B periodontitis after placement of 3mg melatonin film and placebo film along with open flap debridementTimepoint: At 1 week,4 week and 8 week—

Secondary

MeasureTime frame
1.To evaluate pain perception using Visual Analogue Scale (VAS) patients after placement of 3mg melatonin film along with open flap debridement. 2.To evaluate pain perception using Visual Analogue Scale (VAS) after placement of placebo film along with open flap debridement . 3.To compare pain perception in patients after placement of 3mg melatonin film & placebo film along with open flap debridement. 4.To evaluate using Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD)Timepoint: At 1 week,4weeks,8weeks.—

Countries

India

Contacts

Public ContactShruti Bendke

K.B.H. Dental College and hospital,Panchavati,Nashik.

drsamahale@gmail.com9422764080

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026