A Study on Two Fluoride Treatments to Keep Children s Teeth Healthy

COMPARATIVE ASSESSMENT OF CONVENTIONAL AND ARGININE ENRICHED FLUORIDE VARNISHES ON CARIES INCREMENT, SALIVARY FLUORIDE ION CONCENTRATION AND ORAL MICROBIAL PROFILE : AN INVIVO STUDY - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/0104782

Enrollment

Registered

2026-02-25

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 2%L-Arginine enriched MI varnish: 200mg of L-arginine will be mixed with 10ml of MI varnish. To assure the homogenous incorporation the mixture will be sonicated for 10min using an ultr

Eligibility

Inclusion criteria

Inclusion criteria: 1.Children within 6-10 years of age of both the genders 2.Children at risk with 2 or more carious teeth. 3.Co-operative behavior (Frankl scale rating 3-4). 4.Good general health, no systemic diseases affecting saliva or oral health.

Exclusion criteria

Exclusion criteria: 1.Allergies to fluoride, arginine or varnish components. 2.Children requiring special health care needs. 3.Pulpally involved and grossly decayed teeth 4.Professional fluoride application, antibiotics or fluoride supplements within 3 months prior.

Design outcomes

Primary

Measure	Time frame
Caries Increment measured using ICDAS II score Timepoint: Baseline and 6 month	—

Secondary

Measure	Time frame
Salivary Fluoride Ion Concentration measured using UV Spectrophotometry (SPADNS method). Streptococcus mutans Count cultured on Mitis-Salivarius-Bacitracin agar media and measured.Timepoint: Baseline, 1 month and 3 month	—

Countries

India

Contacts

Public ContactDr Balasubramani

Rajarajeswari Dental College and Hospital Bangalore

amrutha.b87@gmail.com8105700221

Outcome results