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Effect of Esmolol Infusion on Recovery in Adults After Major Abdominal Surgery

Effect of perioperative ESmolol infusion on QUality of REcovery (ESQUaRE Trial) in adults undergoing major abdominal surgery under general anaesthesia: a randomized, double-blind, placebo-controlled trial. - ESQUaRE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102646
Enrollment
264
Registered
2026-01-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K319- Disease of stomach and duodenum, unspecified Health Condition 2: K660- Peritoneal adhesions (postprocedural) (postinfection)

Interventions

Intervention1: Esmolol group: 0.5 mg per kg IV over 1 minute after induction followed by infusion- 50 mcg prkg per min) (20 ml in infusion pump at 1200 ml per h ). The infusion will be titrated to a t

Sponsors

AIIMS BHubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18-60 years, classified as ASA physical status I-III, scheduled for elective non-cardiac surgery under general anesthesia with an expected duration of at least 120 minutes and a postoperative hospital stay of at least 24 hours, who are able to provide informed consent and complete the QoR-15 questionnaire.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
QoR-15 scoreTimepoint: 24 h

Secondary

MeasureTime frame
QoR-15 scoreTimepoint: 48 h, 72 h and 1 week;Intraoperative fentanyl consumption between the groupsTimepoint: Intraoperative;postoperative opioid consumption in morphine equivalentsTimepoint: 24 hours;Hemodynamic parameters (HR and MAP)Timepoint: At the time of induction and extubation;Time to extubationTimepoint: Nil;Use of vasoactive drugsTimepoint: Nil;Trop TTimepoint: Baseline, 24 and 48 h;Incidence and severity of chronic painTimepoint: at 3 months

Countries

India

Contacts

Public ContactPooja Bihani

All India Institute of Medical Sciences, Bhubaneswar

drpooja.bihani@gmail.com9694490440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026