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To measure intracranial pressure in traumatic brain injury patient using etomidate or propofol.

Comparison of anesthetic induction with etomidate versus propofol on intracranial pressure with traumatic brain injury: A Randomized trial - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102639
Enrollment
46
Registered
2026-01-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury Health Condition 2: S064- Epidural hemorrhage Health Condition 3: S063- Focal traumatic brain injury Health Condition 4: S068- Other specified intracranial injuries Health Condition 5: S061- Traumatic cerebral edema Health Condition 6: S066- Traumatic subarachnoid hemorrhage Health Condition 7: S065- Traumatic subdural hemorrhage Health Condition 8: S069- Unspecified intracranial injury

Interventions

Intervention1: Anesthetic induction with etomidate: Patient will undergo anesthetic induction with etomidate 0.3 mg per kg, intravenously, only once at the time of anesthetic induction, duration will

Sponsors

Dr Sita Thakur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age between 18 years to 99 years

Exclusion criteria

Exclusion criteria: (i)Refusal to participate in the study (ii) Pregnancy (iii) Fractures of orbital bone or frontal bone (iv) Contra-indication to the anesthetic drugs being used in this study protocol (v) ASA IV, V and VI physical status of the patient (vi) Patient already intubated outside the operation theater

Design outcomes

Primary

MeasureTime frame
Mean Intracranial pressure difference between groups at each time pointTimepoint: Baseline, At the end of pre-oxygenation, After induction, After intubation, At the end of anesthesia protocol, IN Post Anaesthesia Care Unit after 30 minutes and 60 minutes.

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Kunal Kumar

Indira Gandhi Government Medical College

aayushiu09@gmail.com7508423907

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026