Health Condition 1: H188- Other specified disorders of cornea
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology
Eligibility
Inclusion criteria
Inclusion criteria: a)Non healing microbial keratitis bacterial fungal or parasitic unresponsive to standard medical therapy for 2 weeks or earlier in case of advanced ulcer b)Corneal perforation of more than 2mm in size due to infectious cause c)Descemetocele leading to impending perforation of the cornea d)Advanced corneal ulcers size of more than 5mm and involving the posterior two thirds of the corneal stroma
Exclusion criteria
Exclusion criteria: a)Patients with viral keratitis b)Cases where the primary diagnosis is not microbial keratitis c)Infectious infiltration involving the limbus or sclera d)Patients with a history of corneal surgery within the 12 months preceding the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the incidence of graft infections following TPK within the first 3 months post-transplantation. This will be quantified as the proportion of patients who develop a confirmed graft infection during this period.Timepoint: 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time to onset of graft infection: The time interval between TPK and the diagnosis of the first graft infection. 2. Impact of donor-related variables on infection rates: The association between donor age, cause of death, death-to-preservation time, location of corneal retrieval, and method of preservation/transport, and the occurrence of post-TPK graft infections. 3. Influence of preoperative microbial flora on postoperative graft outcomes: The relationship between the microorganisms identified on preoperative corneal cultures and the subsequent development of graft infections, as well as the overall anatomical and visual outcomes of TPKTimepoint: 12 months | — |
Countries
India
Contacts
Public ContactDr Tejaswi Prasad P V
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology
Outcome results
None listed