Skip to content

A Clinical Study Comparing Methods Used to Clean Root Canals and Reduce Infection

Comparative Evaluation of Ultrasonic and Laser-Activated Irrigation on Intracanal Microbial Load Reduction: An In Vivo Microbiological Study. - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102509
Enrollment
51
Registered
2026-01-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: ULTRASONIC ACTIVATED IRRIGATION: 2ml of 3% NaOCl will be used to irrigate canals which will be activated Three times with ultrasonic activtor for 30s each , resulting in 6ml of NaOCl a

Sponsors

Dr. Nikita Agarwal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: c. Symptomatic single rooted teeth with single root canal requiring root canal treatment. d. Teeth with sound periodontal apparatus. e. Teeth without anatomic variations. f. Teeth with sinus tract. g. Teeth without history of trauma.

Exclusion criteria

Exclusion criteria: a. Teeth with previous endodontic treatment b. Teeth with fractures, resorption c. Pregnant or lactating women d. Teeth with incompletely formed roots or open apices

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the antimicrobial efficacy of ultrasonic-activated irrigation, diode-laser irradiated irrigation, and conventional irrigation using 3% sodium hypochlorite in reducing intracanal microbial load in single-rooted tooth canals.Timepoint: Baseline (immediately after access cavity preparation), 3 days (after canal irrigation and mechanical debridement)

Secondary

MeasureTime frame
1. Comparison of percentage reduction in CFU counts among the three groups conventional, ultrasonic-activated, & diode laser-activated irrigation. 2. Determination of the most effective activation technique in achieving maximal microbial reduction. 3. Assessment of smear layer removal efficacy indirectly through enhanced microbial reduction following activation. 4. Correlation of microbial reduction with irrigation method to determine the overall disinfection efficiency of each technique. Timepoint: Baseline (immediately after access cavity preparation), 3 days (after canal irrigation & mechanical debridement)

Countries

India

Contacts

Public ContactNIKITA AGARWAL

AIIMS GUWAHATI

krishnabiswas@aiimsguwahati.ac.in8248137387

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026