To compare and evaluate the amount of penetration of radiopaque dye and reduction of pain after completion of root canal preparation using different types of root canal irrigants in root canal treatment.

Comparative evaluation of apical depth penetration and postoperative pain using 9% 1-Hydroxyethylidene-1, 1-Diphosphonic Acid (HEDP) as continuous chelation and 5% glycolic acid, 10% glycolic acid,17% EDTA as sequential chelation using sonic irrigation technique in symptomatic vital teeth: A double blinded randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102495

Enrollment

Registered

2026-01-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues

Interventions

Intervention1: Root canal irrigation with 17% EDTA: During root canal preparation along with NaOCl, 17% EDTA will be used as a root canal irrigant after every file. Control Intervention1: 5% glycolic

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients aged between 18-40 years. 2. Adult permanent symptomatic anterior or posterior teeth requiring treatment. 3. Pain at NRS scale above 4 cm level. 4. Feasibility of isolation of the tooth with a rubber dam. 5. Participants with the ability to understand the consent forms

Exclusion criteria

Exclusion criteria: 1. Perforation cases 2. Periodontally compromised tooth. 3. Patients not willing for the treatment 4. Patients allergic to iodine. 5. Non-negotiable canals

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the apical depth penetration using 9% HEDP in combination with Sodium hypochlorite (NaOCl), 5% glycolic acid, 10% glycolic acid, and 17% EDTA as sequential chelation using sonic irrigation technique in symptomatic vital teeth.Timepoint: After procedure	—

Secondary

Measure	Time frame
To evaluate and compare the post-operative pain using 9% HEDP in combination with Sodium hypochlorite (NaOCl), 5% glycolic acid, 10% glycolic acid, and 17% EDTA as sequential chelation using sonic irrigation technique in symptomatic vital teeth.Timepoint: Post operative pain will be checked after 6, 24 and 48 hours.	—

Countries

India

Contacts

Public ContactDr Vineeta Nikhil

Subharti Dental College and Hospital/Swami Vivekanand Subharti University

endobyvineeta@gmail.com9639002866

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026