Comparision of intravenous lignocaine (local anaesthetic) + sub anaesthetic (low dose) ketamine (intravenous induction agent) versus scalp block (regional anesthesia) in blunting the fight or flight response to skull pin head holder application in elective craniotomy.

Comparision of sub-anaesthetic dose of intravenous ketamine plus lignocaine versus lignocaine scalp block in blunting the sympathetic response to skull pin head holder application for elective.craniotomy- a non inferiority trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102470

Enrollment

Registered

2026-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous lignocaine plus ketamine: Intravenous lignocaine will be given as a bolus dose of 1.5 mg/kg followed by an intravenous infusion of lignocaine at 1.5 mg/kg/hr for 10 minutes

Eligibility

Inclusion criteria

Inclusion criteria: a.Patients in age group 18-60 years, both males and females. b.Patients posted for elective craniotomy. Patients with ASA PS 1-3.

Exclusion criteria

Exclusion criteria: a.Patients with pre-operative GCS less than 8/15. b.Patients allergic to drugs used in the study. c.Patients with co-morbidities like uncontrolled hypertension, coronary artery disease, heart failure,chronic liver disease, BMI greater than 30kg/m2, seizure disorders. d.Pregnant women.

Design outcomes

Primary

Measure	Time frame
Subanesthetic dose of intravenous ketamine with lignocaine is non-inferior to scalp block in blunting the hemodynamic responses to skull pin application for craniotomy.Timepoint: The heart rate and blood pressure will be measured in both the groups of patient immediately after application of skull pin head holder and there after at 1 minute 2 minutes 5 minutes 10 minutes and 15 minutes	—

Secondary

Measure	Time frame
Quantifying the requirement of rescue intravenous fentanyl boluses in both the groupsTimepoint: At the end of 15 minutes after the application of skull pin head holder	—

Countries

India

Contacts

Public ContactDr Kruti Jain

All India Institue of Medical Sciences, Raipur

subrat@aiimsraipur.edu.in8518881767

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026