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Role of citicoline and cerebrolysin in the management of severe traumatic brain injury a prospective randomized study.

Role of Citicoline and Cerebrolysin combination in the management of severe traumatic brain injury: A Prospective Randomized Study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102466
Enrollment
60
Registered
2026-01-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S069- Unspecified intracranial injury

Interventions

Intervention1: Injection Citicoline and Injection Cerebrolysin: Injection citicoline three grams intravenous once daily for fourteen days and injection cerebrolysin thirty milliliters intravenous once

Sponsors

King Georges Medical University, Lucknow
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18 to 65 years with severe traumatic brain injury defined as Glasgow Coma Scale less than or equal to 8, admitted within 24 hours of injury, with CT scan evidence of traumatic brain injury, requiring intensive care management.

Exclusion criteria

Exclusion criteria: Postoperative TBI; NCCT evidence of midline shift or herniation; pre-existing renal/hepatic failure; pregnancy; known hypersensitivity to Citicoline or Cerebrolysin.

Design outcomes

Primary

MeasureTime frame
Change in Serum Neuron-Specific Enolase (NSE) levelsTimepoint: Baseline (Day 0), Day 7, and Day 14.—

Secondary

MeasureTime frame
Improvement in Glasgow Coma Scale (GCS) scoreTimepoint: Daily from Admission to Day 14.;Functional outcome via Glasgow Outcome Scale (GOS).Timepoint: At discharge and 3-month follow-up;Total Length of Hospital Stay and 14-day Mortality.Timepoint: During hospital stay.—

Countries

India

Contacts

Public ContactOBILI Manoj

King Georges Medical University Lucknow

vipintheazad@gmail.com6387908355

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026