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Comparing intrathecal morphine with epidural morphine for postoperative pain in patients undergoing surgery for gynecologic malignancy

Comparison of analgesic efficacy of intrathecal morphine versus epidural morphine in equivalent doses for postoperative pain in patients undergoing laparotomy for gynecologic malignancy- A Randomized controlled trial. - Nil

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102456
Enrollment
50
Registered
2026-01-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C55- Malignant neoplasm of uterus, partunspecified

Interventions

Intervention1: Intrathecal morphine: Patients will receive intrathecal morphine 5 mcg/kg in 1 ml normal saline along with thoracic epidural and General Anaesthesia Control Intervention1: Epidural morp

Sponsors

Delhi State Cancer Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I-III, undergoing elective laparotomy for gynecologic malignancy under anesthesia

Exclusion criteria

Exclusion criteria: Patient with infection at the site of injection for central neuraxial block, coagulopathy, spine deformity, pre-existing neurological deficit, history of chronic pain, patients on opioids preoperatively, drug addicts, use of analgesia in last 48 hrs before surgery, previous abdominal surgeries, psychiatric disease, liver disease, cardiac disease, renal failure, patients requiring postoperative mechanical ventilation

Design outcomes

Primary

MeasureTime frame
Total fentanyl consumption intraoperatively and postoperatively in 24 hrsTimepoint: Total fentanyl consumption intraoperatively and postoperatively in 24 hrs

Secondary

MeasureTime frame
NRS at rest every hourly upto 24 hrsTimepoint: every hourly postoperatively upto 24 hrs;Duration of effective analgesiaTimepoint: postoperatively;Adverse effectsTimepoint: upto 24 hrs postoperatively;Patient satisfactionTimepoint: 24 hrs postoperatively

Countries

India

Contacts

Public ContactDr Anuradha Patel

Delhi State Cancer Institute

patelanuradha20@gmail.com9205772036

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026