A study comparing two ways of giving esmolol to reduce stress on the heart during tube insertion for anesthesia

A prospective comparative study of esmolol bolus vs esmolol infusion to attenuating hemodynamic responses during laryngoscopy and endotracheal intubation - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102415

Enrollment

Registered

2026-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: ESMOLOL INFUSION: Inj.esmolol 0.2mg/kg/min iv 10 minute before induction to 5 minute after incision and monitor for 20minutes Control Intervention1: ESMOLOL BOLUS: Inj.esmolol 1mg/kg iv

Eligibility

Inclusion criteria

Inclusion criteria: Patients willing to sign informed consent.Male or female patients between 18to60 years of age.Patients belonging to American Society of Anesthesiologists (ASA) physical statusI andII.Patients posted for elective surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patients unwilling to participate in the study. Patients with Body Mass Index more than or equal to 30. Patients with history of muscular disorder,myositis,or any local infection. Bradycardia HR less then 70bpm. Patients with cardiovascular diseases,arrhythmias,heartblocks, or taking beta-blockers.Patients with cerebrovascular, hepatic and renal diseases. Psychiatric patients. Patients with history of allergy to an alpha 2 adrenergic agonist. Pregnancy & lactating women.

Design outcomes

Primary

Measure	Time frame
This prospective and observational study will help us to compare the efficacy between iv bolus and iv infusion of esmolol in attenuating hemodynamic responses to laryngoscopy and endotracheal intubation in patients undergoing surgeries under general anaesthesia.Timepoint: 0 to 20minutes	—

Secondary

Measure	Time frame
To observe any kind of side effects or adverse effects intraoperatively after giving bolus dose or infusion of esmolol.Timepoint: 0 to 20 minutes	—

Countries

India

Contacts

Public ContactDr Dinesh Chauhan

Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre

drdinesh77@gmail.com9099014672

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026