A RANDOMIZED CONTROLLED CLINICAL TRIAL TO COMPARE THE EFFICACY OF AN ALLOPLAST WITH OR WITHOUT â??ADVANCED-PRF+â? USING MINIMALLY INVASIVE SURGICAL TECHNIQUE IN THE MANAGEMENT OF PERIODONTAL INFRABONY DEFECTS

A RANDOMIZED CONTROLLED CLINICAL TRIAL TO COMPARE THE EFFICACY OF AN ALLOPLAST WITH OR WITHOUT â??ADVANCED-PRF+â? USING MINIMALLY INVASIVE SURGICAL TECHNIQUE IN THE MANAGEMENT OF PERIODONTAL INFRABONY DEFECTS - NIL

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102412

Enrollment

Registered

2026-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Alloplast : Nanocrystalline hydroxyapatite graft Control Intervention1: Alloplast + A-PRF+: Nanocrystalline hydroxyapatite graft + A-PRF+ with patients blood

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with age more than or equal to 18 with periodontitis. 2. Patients with at least one or more sites with periodontal probing depth (PD) more than or equal to 5 mm when measured using a manual periodontal probe (UNC 15) and CAL more than or equal to 5 mm. 3. Radiographic presence of at least one infrabony osseous defect having depth more than or equal to 3 mm as measured. 4. Patients who will have full-mouth plaque score(FMPS) and full-mouth bleeding score(FMBS) less than or equal to 20 percent 5. Patients who will give consent for participation in the study and shall also be available for all follow periods.

Exclusion criteria

Exclusion criteria: 1. Patients with any known systemic disease and drug or medication or therapeutic regimen that might interfere with wound healing of soft tissue or bone. 2. Patients who have habit of smoking and or consuming alcohol. 3. Patients allergic to any drug and or material, used in the study. 4. Patients unable or unwilling to undergo surgical procedure. 5. Patients who are pregnant or lactating females. 6. Patients who had undergone periodontal treatment in the previous 6 months. 7. Patients with parafunctional habits such as bruxism. 8. Defect sites with teeth having more than or equal to Grade II furcation involvement. 9. Defect Sites with teeth having mobility more than or equal to Grade III. 10. Defect sites around third molar.

Design outcomes

Primary

Measure	Time frame
A. Clinical Parameters i. Clinical attachment level (CAL) ii. Pocket depth (PD) B. Radiographic parameters i. Defect depth ii. Amount of defect fill iii. Percentage of defect fill iv. Amount of defect resolution v. Percentage of defect resolution Timepoint: baseline 12 weeks 24 weeks	—

Secondary

Measure	Time frame
Clinical Parameters- i. Plaque index (PI) ii. Gingival bleeding index (GBI) Timepoint: Baseline 12 weeks 24 weeks	—

Countries

India

Contacts

Public ContactDr Priyanshi

J.N Kapoor D.A.V Centenary Dental College

priyanshibajaj08@gmail.com8059589447

Outcome results