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Effect of Warmed and Cooled 4 Percent Articaine on Inferior Alveolar Nerve Block Success in Mandibular First Molars with Irreversible Pulpitis: A Double-Blind Randomized Trial

Impact of Temperature-Conditioned 4 Percent Articaine on Effectiveness of Inferior Alveolar Nerve Block in Mandibular First Molars With Symptomatic Irreversible Pulpitis: A Double-Blind Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102348
Enrollment
150
Registered
2026-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: local anesthesia (articaine) at cold temperature: local anesthesia (articaine 1.7ml) administered by inferior alveolar nerve block at cold temperature 4-6 degrees Celsius Intervention2:

Sponsors

Dr Mansi Jain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Mandibular first permanent molars diagnosed with symptomatic irreversible pulpitis Presence of deep carious lesions approximating/involving the pulp Positive response to cold test and/or electric pulp testing Absence of periapical pathosis on radiographic examination

Exclusion criteria

Exclusion criteria: Patients with known allergy to articaine or sulfites Teeth with necrotic pulp or acute apical abscess Patients on analgesics, within 12 hours prior to treatment Pregnant or lactating women Systemic conditions contraindicating local anesthesia Any re-RCT treatment case Patients with chronic pain Patients with neuropathic, psychiatric, genetic, metabolic, inflammatory or autoimmune disorders Presence of periodontal disease

Design outcomes

Primary

MeasureTime frame
effectiveness and pain perception assessment of local anesthesia at different temperatureTimepoint: Pain perception will be measured before the administration of the local anaesthesia, after administration while entering into the pulp chamber and after entering into the canals

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Shweta Verma

Himachal Dental College and Hospital

drshwetaverma053@gmail.com9418476681

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026