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Change in Blood Volume Getting Pumped Out of the Heart Before and After Passively Raising the Legs of a Patient on Ventilator as a Predictor of Liberation from Ventilator in the Intensive Care Unit - A Prospective Observational Study

Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) Change to Passive Leg Raise for Prediction of Extubation Failure in the Intensive Care Unit: A Prospective Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/01/102303
Enrollment
60
Registered
2026-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I00-I99- Diseases of the circulatory system Health Condition 2: G00-G99- Diseases of the nervous system Health Condition 3: J00-J99- Diseases of the respiratory system

Interventions

Intervention1: Nil: Nil

Sponsors

Vinayak S R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients who underwent extubation following a successful SBT and who had been on mechanical ventilation for more than 24 hours, Stable oxygenation (FiO2 less than 0.5, PEEP less than or equal to 5 cm H2 O) A respiratory rate of less than 30 breaths per minute, An absence of fever, Alert and cooperative, Hemodynamically stable, The absence of high doses of vasopressor therapy (requirement of norepinephrine more than 0.1 mcg per kg per min or equivalent vasopressor doses).

Exclusion criteria

Exclusion criteria: Patients with spinal cord injuries above the T8 level, Presence of significant cardiac arrhythmia, Diaphragmatic paralysis, ICU-acquired neuromyopathy, Planned noninvasive ventilation (NIV) following extubation Poor ultrasound windows.

Design outcomes

Primary

MeasureTime frame
Evaluate whether a percent change in Left ventricular Outflow Tract Velocity Time Integral following passive leg raise (PLR) (performed before SBT) predicts weaning failureTimepoint: At any point following extubation during the stay in the Intensive Care Unit—

Secondary

MeasureTime frame
To evaluate the predictive value of diaphragmatic ultrasound (Diaphragmatic Thickening Fraction & Diaphragmatic Excursion) for weaning failureTimepoint: At any point following extubation during the stay in the Intensive Care Unit;To identify independent predictors of failure using a binary logistic regression modelTimepoint: At any point following extubation during the stay in the Intensive Care Unit—

Countries

India

Contacts

Public ContactVinayak S R

Aster Medcity, Kochi, Kerala

dranuroop.balagopal@asterhospital.in9447473376

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026