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A Study comparing effectiveness of nasal nerve block for treating facial pain not responding to medications using local anaesthetic , local anaesthetic with steroid versus placebo

Comparison of Sphenopalatine ganglion block efficacy via transnasal approach using lignocaine , lignocaine with dexamethasone versus placebo in patients of trigeminal neuralgia refractory to pharmacotherapy- A Prospective Randomized control trial - SPG-TREAT

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102286
Enrollment
72
Registered
2026-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G440- Cluster headaches and other trigeminal autonomic cephalgias (TAC)

Interventions

Intervention1: Lignocaine 4 percent: Group L: patients will undergo transnasal Sphenopalatine ganglion block with 2 ml lignocaine 4% and 1 ml normal saline. 3 times application in interval of 24 hour

Sponsors

Institute of Medical Sciences Banaras Hindu University
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed case of trigeminal neuralgia refractory to pharmacotherapy having severe pain belonging to ASA physical status I-III.

Exclusion criteria

Exclusion criteria: 1.Patients undergone previous treatment with Radiofrequency ablation. 2.Any diagnosed/known vascular lesion and anatomical deformity of nose or fracture on affected side. 3. Active nasal discharge. 4. Patients with any other painful conditions for which patients is on analgesic medication. 5.pregnant and lactating females

Design outcomes

Primary

MeasureTime frame
Reduction in pain intensity using NRS and duration of analgesia post procedureTimepoint: At Baseline ,1 week and 2 weeks

Secondary

MeasureTime frame
1.Reduction in frequency of attacks 12 hourly 2.Daily Rescue analgesic requirement till discharge 3.Improvement in Quality of life score and patients satisfaction score. Timepoint: At discharge, 1 week and 2 weeks

Countries

India

Contacts

Public ContactDr Pratima Rathore

Institute of Medical Sciences (IMS),Banaras Hindu University (BHU)

dr.shashi.prakash@gmail.com9453047154

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026