Health Condition 1: 3- Administration Health Condition 2: 4- Measurement and Monitoring
Conditions
Interventions
Intervention1: Low dose SDK: Participants receiving low dose sub dissociative ketamine (0.15 mg per kg IV) as a single bolus infusion over 15 minutes.
Control Intervention1: High dose SDK: Participant
Sponsors
Jawaharlal institute of postgraduate medical education and research
Eligibility
Inclusion criteria
Inclusion criteria: Patients presenting to emergency medicine department with acute severe pain ( more than or equal to 7 on an 11 point numeric rating scale)
Exclusion criteria
Exclusion criteria: Known allergy or hypersensitivity to ketamine, Altered mental status at presentation, Severe psychiatric illness (e.g., active psychosis or schizophrenia) Significant cardiovascular disease, including uncontrolled hypertension (more than 180 by 110 mm Hg), history suggestive of myocardial infarction or aortic dissection, heart failure, End-stage liver disease/ Renal failure (creatinine clearance less than 30 mL/min) History of glaucoma / open globe injuries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the pain reduction between low dose (0.15 mg per kg) vs high dose (0.3 mg per kg) SDK at 15 minutes in older adults presenting to ED with acute pain ( greater than or equal to 7 on the NRS)Timepoint: At 15 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare pain reduction between 0.15 mg per kg vs 0.3 mg per kg SDK at 60 minutesTimepoint: At 60 minutes;To evaluate the incidence and severity of adverse effects in both groups.Timepoint: During the stay at hospital;To compare pain reduction between 0.15 mg per kg vs 0.3 mg per kg SDK at 30 minutesTimepoint: At 30 minutes | — |
Countries
India
Contacts
Public ContactDr Amaravathi U
Jawaharlal institute of postgraduate medical education and research
Outcome results
None listed