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A comparison of the effects of dexmedetomidine and dexamethasone as adjuvants to spinal anaesthesia in elderly patients posted for sugery

INTRATHECAL DEXMEDETOMIDINE (4mcg) VERSUS DEXAMETHASONE (4mg) AS ADJUVANTS TO HYPERBARIC BUPIVACAINE (10mg) IN OLDER PATIENTS UNDERGOING INFRAUMBILICAL SURGERIES UNDER SPINAL ANAESTHESIA : A DOUBLE-BLIND, RANDOMISED TRIAL THE DEX4 DEXA4 TRIAL - Dex4 Dexa4 Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102188
Enrollment
104
Registered
2026-01-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: DEXMEDETOMIDINE 4 microgram and heavy bupivacaine in spinal anaesthesia Control Intervention1: Dexamethasone: dexamethasone 4 mg and heavy bupivacaine 10mg in spinal an

Sponsors

AIIMS GUWAHATI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Male or female patients Age more than 60 years Patients classified as American Society of Anesthesiologists Physical Status I III scheduled for elective infraumbilical surgeries under spinal anaesthesia

Exclusion criteria

Exclusion criteria: Refusal to consent Contraindications for spinal anaesthesia History of hypersensitivity to study drugs Patient on alpha agonist as antihypertensive medication Patient receiving long-term steroid therapy Preexisting neurological or neuromuscular disorders involving lower limbs

Design outcomes

Primary

MeasureTime frame
To compare the duration of postoperative analgesia between the two study groupsTimepoint: Baseline 5 mins 10 mins 15 mins 20 mins 25 mins 30 mins 45 mins 60 mins 90 mins 120 mins 150 mins 180 mins 210 mins 240 mins 60 mins after Surgery 120 mins after Surgery 180 mins after Surgery 240 mins after Surgery 300 mins after Surgery 360 mins after Surgery—

Secondary

MeasureTime frame
time for onset of sensory block Time for onset of motor block Highest level of sensory block Time to reach highest level of sensory block Duration of sensory block Duration of motor block Blood SugarTimepoint: Baseline 5 mins 10 mins 15 mins 20 mins 25 mins 30 mins 45 mins 60 mins 90 mins 120 mins 150 mins 180 mins 210 mins 240 mins 60 mins after Surgery 120 mins after Surgery 180 mins after Surgery 240 mins after Surgery 300 mins after Surgery 360 mins after Surgery Blood Sugar Baseline 4 hours 8 hours 12 hours—

Countries

India

Contacts

Public ContactDrAnkur Khandelwal

AIIMS Guwahati

ankurchintus@gmail.com7042929671

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026