Intranasal Dexmedetomidine vs Placebo for reducing heart rate and blood pressure during Tonsillectomy.

Efficacy of Intranasal Dexmedetomidine in suppressing haemodynamic stress response to Boyle Davis Mouth Gag insertion in patients undergoing Tonsillectomy - A Randomised Double Blinded Placebo Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102099

Enrollment

Registered

2026-01-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J039- Acute tonsillitis, unspecified Health Condition 2: J350- Chronic tonsillitis and adenoiditis

Interventions

Intervention1: Dexmedetomidine: The study involves administration of 1 mcg/kg Dexmedetomidine intranasally 30 mins before intubation in patients undergoing Tonsillectomy to reduce hemodynamic stress

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 5-14 years of age of either sex posted for elective tonsillectomy

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications to Dexmedetomidine 2. Patients with history of congenital heart diseases, heart blocks, hypertension,pre existing sinus bradycardia,obstructive sleep apnoea. 3. Patients care givers not giving the consent

Design outcomes

Primary

Measure	Time frame
1.Heart rate 2.Blood pressure 3.Mean Arterial PressureTimepoint: 1.Heart rate 2.Blood pressure 3.Mean Arterial Pressure These study variables are measured at Baseline Before mouth gag insertion Immediately after mouth gag insertion Post mouth gag insertion 2 mins Post mouth gag insertion 4 mins Post mouth gag insertion 6 mins Post mouth gag insertion 8 mins Post mouth gag insertion 10 mins Post mouth gag insertion 15 mins Post mouth gag insertion 30 mins Post mouth gag insertion 45 mins Post mouth gag insertion 60 mins During extubation Post extubation 10 mins	—

Measure

Time frame

1.Heart rate 2.Blood pressure 3.Mean Arterial PressureTimepoint: 1.Heart rate 2.Blood pressure 3.Mean Arterial Pressure These study variables are measured at Baseline Before mouth gag insertion Immediately after mouth gag insertion Post mouth gag insertion 2 mins Post mouth gag insertion 4 mins Post mouth gag insertion 6 mins Post mouth gag insertion 8 mins Post mouth gag insertion 10 mins Post mouth gag insertion 15 mins Post mouth gag insertion 30 mins Post mouth gag insertion 45 mins Post mouth gag insertion 60 mins During extubation Post extubation 10 mins

—

Secondary

Measure	Time frame
Demographic details Age, Weight, HeightTimepoint: Baseline	—

Countries

India

Contacts

Public ContactGayatri Mishra

Mahatma Gandhi Medical College and Research Institute , Pondicherry.

drgayatrimishra@gmail.com9894354068

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026