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A study on confusion after surgery in elderly patients reversed with neostigmine or sugammadex after general anaesthesia

A comparative analysis of the incidence of postoperative delirium in ASA I-II geriatric patients undergoing general anaesthesia after reversal with neostigmine vs. sugammadex - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/102082
Enrollment
80
Registered
2026-01-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Neostigmine with glycopyrrolate: according to american society of anesthesiologists (asa) physical status classification system grade i ii geriatric patients und

Sponsors

Dr Gargi Ahalawat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: american society of anesthesiologists ASA physical status I or II Elective non-cardiac , non-neuro surgery under general anesthesia Expected duration of surgery less than 2 hours. Use of vecuronium as neuromuscular blocker Planned reversal with either neostigmine or sugammadex MMSE score more than or equal to 24 (normal preoperative cognitive status) Hemodynamically stable intraoperatively Able to provide informed consent Proficient in the language used for cognitive or delirium assessment Postoperative care planned in PACU followed by ward admission

Exclusion criteria

Exclusion criteria: ASA physical status III or higher Emergency surgeries Known neurological or psychiatric disorders Preoperative cognitive impairment (MMSE less than 24) Allergy or contraindication to neostigmine or sugammadex Recent use of benzodiazepines, anticholinergics, or antipsychotics Significant renal (eGFR less than 30 ml per min per 1.73m ) or hepatic dysfunction Intraoperative hemodynamic instability or unplanned ICU admission Communication barriers (language, severe hearing or vision impairment, aphasia) History of alcohol or substance abuse Participation in another clinical trial within the past 3 months

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the incidence of postoperative delirium (POD) in geriatric patients (age more than or equal to 60 years) with ASA physical status I or II, undergoing general anesthesia with neuromuscular blockade reversed using neostigmine versus sugammadexTimepoint: at 2 hours, 6 hours, 12 hours , 24 hours and 48 hours postoperatively 2 months—

Secondary

MeasureTime frame
To assess the time to emergence and extubation in both groups following administration of the reversal agentTimepoint: at 2 hours, 6 hours, 12 hours , 24 hours and 48 hours postoperatively 2 months—

Countries

India

Contacts

Public ContactDr Gaurav Kumar

Varun arjun medical college and rohilkhand hospital

rajeev.smch@gmail.com7839310269

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026