None listed
Conditions
Interventions
Intervention1: Caffeine: Caffeine will be administered orally in the form of a caffeinated drink at a dose of three milligram per kilogram body weight. This is considered a moderate and safe dose base
Sponsors
AIIMS Bhopal
Eligibility
Inclusion criteria
Inclusion criteria: Male participants aged 18 to 29 years Right handed individuals Apparently healthy volunteers capable of providing written informed consent
Exclusion criteria
Exclusion criteria: Overweight or obese participants with body mass index more than 25 Self reported history of tobacco use in any form History of epilepsy or seizures Presence of metallic implants or any contraindication to transcranial magnetic stimulation History of neuropsychiatric disorders History of chronic debilitating illness History of intellectual disability History of brain trauma or brain surgery Current or recent use of any prescription or non prescription drugs that may affect cortical excitability or caffeine metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corticomotor excitability will be assessed using single-pulse TMS. The primary outcome will be resting motor threshold (MT). Secondary outcomes will include motor evoked potential (MEP) amplitude and MEP latency.Timepoint: Bassline to 2 Month | — |
Secondary
| Measure | Time frame |
|---|---|
| Reaction time performance will be assessed by measuring simple and choice reaction time (RT), defined as the time taken by the participant to execute a mechanical response following the presentation of single and multiple visual stimuli, respectively. Error percentage will also be recorded. Reaction time will be measured using the open-access and user-friendly Computerized Reaction Time Test (Deary Liewald Reaction Time Task).Timepoint: Bassline to 2 Month | — |
Countries
India
Contacts
Public ContactDr Santosh L wakode
AIIMS Bhopal
Outcome results
None listed