This study compares two sets of medicines to see which one works better in preventing nausea and vomiting caused by oxytocin during surgery. One group receives ondansetron with dexamethasone, and the other group receives metoclopramide with dexamethasone.

Comparison of ondansetron with dexamethasone versus metoclopramide with dexamethasone for intraoperative oxytocin induced nausea and vomiting A randomised comparative study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102066

Enrollment

Registered

2026-01-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Ondansetron with dexamethasone versus Metoclopramide with dexamethasone: Oxytocin will be given intravenously after delivery/manipulation. Group O will receive Ondansetron 4 mg + Dexame

Eligibility

Inclusion criteria

Inclusion criteria: Female patients under reproductive age group between 18 and 40 years. Patient under ASA physical status I or II. Patients undergoing elective cesaerean or gynaecological surgery under spinal anaesthesia. Patients receiving exclusively oxytocin intraoperatively.

Exclusion criteria

Exclusion criteria: Patients receiving Carboprost and Methergine. Patients with history of motion sickness or postoperative nausea and vomiting. Patients with prior antiemetic use within 24 hours. Patients with known allergy to study drugs. Patients with BMI more than 30 kg per m . Procedures that get converted to general anaesthesia. Patients with pre existing GI, neurological, or psychiatric disorders.

Design outcomes

Primary

Measure	Time frame
Incidence of intraoperative vomiting after oxytocin administration, from administration until the end of surgery, comparing ondansetron and dexamethasone versus metoclopramide and dexamethasone.Timepoint: 30 MINUTES	—

Secondary

Measure	Time frame
To assess the severity & frequency of vomiting episodes in both groups To determine the need for rescue antiemetics in both treatment arms To identify any adverse drug reactions associated with the use of either combination therapy Timepoint: 30 MINUTES	—

Countries

India

Contacts

Public ContactDr Saundarya R

Shri Sathya Sai Medical College And Research Institute

saundaryaraja55@gmail.com7338520220

Outcome results