Comparison of oral pregabalin and intravenous lignocaine to check stability of hemodynamic parameters during laryngoscopy and intubation in patients undergoing general anesthesia

Oral pregabalin versus intravenous lignocaine for hemodynamic stability during direct laryngoscopy and intubation in patients undergoing general anesthesia A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102037

Enrollment

Registered

2026-01-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Oral Pregabalin: Oral Pregabalin 150mg given 1 hour prior to surgery Control Intervention1: Intravenous Injection Lignocaine: Injection Lignocaine 1.5mg/kg intravenous to be given 90 se

Eligibility

Inclusion criteria

Inclusion criteria: Participants scheduled for elective surgeries under general anesthesia ASA I and II Patient willing to participate in study

Exclusion criteria

Exclusion criteria: Anticipated difficult airway Pregnancy Patients on sedatives, antidepressants and antipsychotic medication Time taken for intubation exceeds 20 seconds Patient unwilling to participate in study

Design outcomes

Primary

Measure	Time frame
To compare oral Pregabalin and intravenous Lignocaine for hemodynamic stability during laryngoscopy and intubation in patients undergoing general anesthesia in terms of alterations in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressureTimepoint: Above points will be observed at baseline, preinduction, at the time of laryngoscopy, 1 min,3 mins, 5 mins, 10 mins and 15 mins after intubation	—

Measure

Time frame

To compare oral Pregabalin and intravenous Lignocaine for hemodynamic stability during laryngoscopy and intubation in patients undergoing general anesthesia in terms of alterations in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressureTimepoint: Above points will be observed at baseline, preinduction, at the time of laryngoscopy, 1 min,3 mins, 5 mins, 10 mins and 15 mins after intubation

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Saad Jamadar

NKP Salve Institute Of Medical Sciences And Research Centre And Lata Mangeshkar Hospital

tilkavghate@gmail.com8446095872

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026