Use of Vitamin C mixed blood concentrate to Improve Healing and Reduce Discomfort After Gum Color Lightening Treatment

The Effect of adjunctive Ascorbic Acid Augmented Injectable Platelet-Rich Fibrin on healing and Patient-Reported Outcomes Following Gingival Depigmentation: A Randomized split mouth clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/102022

Enrollment

Registered

2026-01-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: Ascorbic acid augmented platelet rich fibrin: VESCO pharma ascorbic acid 1000mg mixed in blood before centrifugation Intervention2: Ascorbic acid: VESCO pharma ascorbic acid 1000mg Inte

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients age range of 20 to 50 years with gingival hyperpigmentation (Dummet s index 2 3)

Exclusion criteria

Exclusion criteria: 1.Patients with systemic diseases 2.Smokers 3.Patients consuming alcohol 4.Patients under anti-coagulant therapy 5.Patients who are allergic to ascorbic acid 6.Pregnant and lactating women and 7.Patients who have consumed antibiotics within the last 3 months

Design outcomes

Primary

Measure	Time frame
DUMMETS Oral pigmentation indexTimepoint: 1 month,3 months and 6 months	—

Secondary

Measure	Time frame
Re-epithelizationTimepoint: 1 & 2 weeks	—

Countries

India

Contacts

Public ContactRAYAPATI LOIS SOWMYA ABHINANDHITHA

vishnu dental college

sruthima@gmail.com09492293808

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026