FindTrial
Sign In

Ability of Blood Pressure and Central Venous Pressure Changes in knowing the Fluid bolus response in Septic Shock patients

Diagnostic performance of Combined Central Venous Pressure and Pulse Pressure changes during fluid challenges for predicting Fluid Responsiveness in Septic Shock - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/01/101960
Enrollment
60
Registered
2026-01-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R652- Severe sepsis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

AIIMS Guwahati
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Invasive mechanical ventilation Having septic shock Fluid challenge is indicated presence of central and arterial line for management On norepinephrine less than 0.3 mcg/kg/min and dose unchanged in last 5 minutes RASS less than or equal to -1

Exclusion criteria

Exclusion criteria: Poor echocardiography window Known case of mitral or aortic regurgitation Evidence of acute cor pulmonale or right ventricular failure Obvious severe hypovolemia Requirement of more than 1 vasopressor or inotrope Uncontrolled arrhythmia other than sinus tachycardia/bradycardia

Design outcomes

Primary

MeasureTime frame
Compare the accuracy of combined changes in central venous pressure (CVP) and pulse pressure (PP) during a standardized fluid challenge to predict fluid responsiveness (FR), against change in left ventricular outflow tract velocity time integral (LVOT VTI)Timepoint: 0, 1 min—

Secondary

MeasureTime frame
1. Accuracy of delta CVP for predicting fluid responsiveness 2. Accuracy of Delta PP for predicting fluid responsiveness 3. Assessment of the association between delta CVP and delta PP categories and fluid responsiveness after adjusting for co-variatesTimepoint: 0. 1 min—

Countries

India

Contacts

Public ContactAnirban Bhattacharjee

AIIMS Guwahati

drhabibkarim@gmail.com9612372585

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026