Comparing Nebulised Fentanyl, Dexmedetomidine and Magnesium to Control Heart Rate and Blood Pressure During Intubation in Adult Surgical Patients

A COMPARATIVE EVALUATION OF NEBULISED FENTANYL, DEXMEDETOMIDINE, AND MAGNESIUM SULPHATE IN MODULATING HAEMODYNAMIC STRESS RESPONSE DURING LARYNGOSCOPY AND TRACHEAL INTUBATION: AN OPEN LABLE, RANDOMIZED, THREE WAY STUDY - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101922

Enrollment

Registered

2026-01-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs Health Condition 2: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: DEXMEDETOMIDINE: MODULATING HAEMODYNAMIC STRESS RESPONSE DURING LARYNGOSCOPY AND TRACHEAL INTUBATION Control Intervention1: FENTANYL: MODULATING HAEMODYNAMIC STRESS RESPONSE DURING LARY

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients aged between 18 and 60 years scheduled for elective surgeries requiring endotracheal intubation under general anaesthesia. 2. Classified as American Society of Anesthesiologists (ASA) physical status I or II. 3. Patients with Mallampati airway classification Grade I or II.

Exclusion criteria

Exclusion criteria: 1. Patients with known drug allergies to study drugs, 2. Individuals with a body mass index (BMI) greater than 30 kg/m , 3. History of severe cardiovascular diseases (such as ischaemic heart disease or uncontrolled hypertension), 4. Patients with a history of alcohol intake or chronic drug use, 5. Pregnant women 6. Cases where tracheal intubation time exceeded 20 seconds.

Design outcomes

Primary

Measure	Time frame
To assess the change in heart rate (HR) from the baseline (before nebulisation) to two minutes after tracheal intubation following administration of nebulised fentanyl, dexmedetomidine, or magnesium sulphate.Timepoint: before nebulization to 2 minutes post intubation	—

Secondary

Measure	Time frame
To analyse variations in Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Mean Arterial Pressure (MAP) Timepoint: before nebulization , after nebulization , 2mins 5mins and 10mins after intubation	—

Countries

India

Contacts

Public ContactDr CHARAN L

SHRI B.M PATIL MEDICAL COLLEGE AND HOSPITAL

drvijaykatti@gmail.com9844585900

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026