Comparison of Fat Graft Tympanic Membrane Closure With and Without 30% Trichloroacetic Acid

Evaluating the Effectiveness of Fat Graft with 30 % Trichloroacetic Acid in comparison to conventional Tympanic Membrane Closure with Fat Graft alone in patients undergoing Myringoplasty : A Single blinded Randomized Controlled Trial - FAT-TCA Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101780

Enrollment

Registered

2026-01-21

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H728- Other perforations of tympanic membrane

Interventions

Intervention1: Using 30 % Trichloroacetic Acid with fat graft: Evaluating the Effectiveness of Fat Graft with 5ml of 30 % Trichloroacetic Acid applied locally when freshening the margins of Tympanic M

Eligibility

Inclusion criteria

Inclusion criteria: Small Sized Central Perforations Small Sized Traumatic Perforations No active discharge for atleast 6 weeks

Exclusion criteria

Exclusion criteria: Marginal or Large Central Perforations Ossicular Chain Pathology Immunocompromised or Diabetic Patients Previous Ear Surgeries

Design outcomes

Primary

Measure	Time frame
Graft UptakeTimepoint: At 3 weeks, 6 weeks and 12 weeks post surgery	—

Secondary

Measure	Time frame
Improvement in hearing, complications and patient satisfactionTimepoint: At 3 weeks, 6 weeks and 12 weeks post surgery	—

Countries

India

Contacts

Public ContactDr Sachin Vejella

Aarupadai Veedu Medical College and Hospital

atulbage25@gmail.com9443292716

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026