Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: Iron Folic Acid Supplementation and Synbiotic supplementation: Iron(60mg) and folic acid (5mg) as per national antenatal care guidelines along with synbiotic supplementation consisting
Sponsors
Dr Balamurugan Ramadass
Eligibility
Inclusion criteria
Inclusion criteria: 1. In their first trimester 2. Singleton pregnancy (confirmed by ultrasound) 3. On Iron and folic acid supplementation 4. Not on any probiotic supplements 5. Willing to consent 6. Available and willing to the follow-up visit.
Exclusion criteria
Exclusion criteria: 1. Having high risk pregnancy(diabetes, hypertension, placenta previa, placental abruption, cervical insufficiency and history adverse outcomes during earlier pregnancy) 2. Known gastrointestinal diseases(chronic diarrhea, ulcerative colitis, Crohns disease) 3.Severe Anemia (Hb less than 7gm per dl 4.Any chronic disease (cardiovascular, hepatic, renal disease, COPD/chronic asthma, immune disorder) 5.Do not comply with iron supplementation. 6.Antibiotic use (oral or systemic) in the last three months. 7.Not willing/able to follow the protocol 8.Not giving consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the differential expression on placental miRNA profile in both groupsTimepoint: Delivery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Changes in maternal cellular miRNA in both groups 2.Changes in umblical cord blood cellular miRNA in both groups. 3.Changes in maternal gut microbiome and diversity in both groups. 4.Correlate gut microbiome metrics with miRNA expression profile in maternal blood, placenta and cord bloodTimepoint: 1.baseline, mid pregnancy (2nd 3rd trimester), and delivery. 2.Delivery 3.baseline and delivery. | — |
Countries
India
Contacts
Public ContactDr Balamurugan Ramadass
AIIMS, Bhubaneswar
Outcome results
None listed