Health Condition 1: I501- Left ventricular failure, unspecified
Conditions
Interventions
Intervention1: dobutamine and glycerile trinitrate: dobutamine infusion at the rate of 10 microgram per kg per minute with glyceryl trinitrate infusion at the rate of 0.6 microgram per kg per minute
I
Sponsors
IPGMER and SSKM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 1 month to 12 years with clinical features corroborating with Class III and IV of modified Ross classification AND With Echocardiography criteria of ejection fraction less than 40%
Exclusion criteria
Exclusion criteria: 1. Parents or patients not giving consent or assent respectively 2. Children who has left ventricular outflow tract obstruction 3. Children with hemodynamically significant congenital heart disease 4. Children with sepsis 5. Children having Arrhythmia 6. Children with heart failure secondary to Hypertension (BP greater than 95 percentile)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of acute heart failure with reduced ejection fraction which is defined by Class I of modified Ross classification. Outcomes are 1. Time to resolve heart failure 2. Maximum dose of drug required 3. Time required to reach the maximum dose Timepoint: baseline, then every 6 hours till heart failure resolves | — |
Secondary
| Measure | Time frame |
|---|---|
| Data about safety of the drugsTimepoint: after heart failure resolves, or if any adverse event occurs;Complications: i) Hypotension ii) Supportive measures e.g. fluid resuscitation, inotropes etc. iii) Whether Furosemide is to be continued during infusion therapy at least @ 2mg/kg/day iv) Other complications not listed above Timepoint: baseline, then every 6 hours till heart failure resolves | — |
Countries
India
Contacts
Public ContactShatanik Sarkar
Institute of Post Graduate Medical Education and Research
Outcome results
None listed