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Use of Probiotics to Reduce Infection and Improve Healing in Chronic Wounds

Effect of Topical Probiotics on Biofilm producing Bacteria in Chronic Wounds: A Randomized Control Trial - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/101644
Enrollment
42
Registered
2026-01-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue

Interventions

Intervention1: Topical Probiotic: Probiotic powder will be applied to a chronic non-healing ulcer along with standard of care treatment. The dressing will be changed every other day for 2 weeks. Wound

Sponsors

MRU AIIMS Rishikesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients coming to the OPD and IPD of surgical departments of AIIMS Rishikesh with chronic wounds (wounds that are not able to heal by 4 weeks 2)Wounds greater than 5 cm in both dimensions which will require skin graft 3)Patients willing to come to the OPD once every 2 weeks week

Exclusion criteria

Exclusion criteria: 1) Patients with AIDS 2) Patients who have had transplant surgery, 3) Patients with Peripheral Vascular Disease,

Design outcomes

Primary

MeasureTime frame
Evaluation of wound cultures for biofilm presence and microbial growth will be performed at the end of 2 weeks of therapy. Therefore, a total of 3 wound cultures will be takenTimepoint: 2 weeks, 4 weeks, and 6 weeks after initiation of therapy

Secondary

MeasureTime frame
Graft survivalTimepoint: 4 weeks after skin grafting

Countries

India

Contacts

Public ContactAkshay Kapoor

All India Institute of Medical Sciences Rishikesh

akshay.7884@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026