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Study to evaluate the effect of Desmopressin nasal application on bleeding control in sinus surgery.

Effect of topical Desmopressin on bleeding and quality of surgical field during Functional Endoscopic Sinus Surgery. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/101509
Enrollment
50
Registered
2026-01-19
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J329- Chronic sinusitis, unspecified

Interventions

Intervention1: Use of Desmopressin nasal spray prior to surgery (Functional endoscopic sinus surgery) in Chronic Rhinosinusitis patients.: 2 puffs of Desmopressin nasal spray in both nostrils 90 minut

Sponsors

Vinayaka missions research foundation
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Candidates of FESS due to chronic rhinosinusitis(with & without polyposis) Candidates with chronic rhinosinusitis with no response to medical therapy Candidates with normal preoperative serum and urine sodium levels Candidates with normal coagulation profile

Exclusion criteria

Exclusion criteria: Revision FESS Coagulopathies, bleeding disorders Candidates on anticoagulants, vitamin E, diuretics , herbal medicines Known allergy to desmopressin Uncontrolled hypertension,cerebrovascular disease, significant coronary artery diseases or arrythmias Compromised renal and hepatic function Hyponatremia Diabetes , seizure disorders Sinonasal tumors Pregnancy

Design outcomes

Primary

MeasureTime frame
To evaluate the effects of topical Desmopressin as a premedication, on intraoperative bleeding and quality of surgical field during FESS.Timepoint: Every 15 minutes intraoperatively till the end of surgery.—

Secondary

MeasureTime frame
To assess the effect of topical Desmopressin on hemodynamic parameters.Timepoint: Every 15 minutes intraoperatively till the end of surgery.—

Countries

India

Contacts

Public ContactDr. Athulya. S

Vinayaka Missions University : Vinayaka Missions Research Foundation (Deemed To Be University)

athummc@gmail.com9895681355

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026