Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Dr Karthik Chandra
Eligibility
Inclusion criteria
Inclusion criteria: Adult greater than 18 years undergoing calculation of Liver Stiffness Index and have reports of Complete Blood Counts and Liver function tests within 3 months of calculation of Liver Stiffness Index
Exclusion criteria
Exclusion criteria: Participants will be excluded from the study if they meet any of the following conditions: 1. Acute Hepatic Injury 2. Pregnancy 3. Haematological Disorders Affecting Platelet Counts 4. Decompensated Cirrhosis 5. Severe Extrahepatic Illnesses 6. Recent Major Physiological Stressors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of this study is the diagnostic performance of existing non-invasive fibrosis scores namely FIB-4, APRI, and FIB-5 in predicting liver fibrosis as assessed by the Liver Stiffness Index (LSI) measured via transient elastography. AUROC (Area Under the Receiver Operating Characteristic Curve) for each score in identifying mild, moderate, and severe fibrosis grades. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each fibrosis score compared to the Liver Stiffness Index. Distribution of fibrosis scores across different LSI strata to evaluate consistency of classification. Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Karthik Chandra
Kasturba Medical College, Manipal
Outcome results
None listed