Health Condition 1: - Health Condition 2: - Health Condition 3: C051- Malignant neoplasm of soft palate
Conditions
Interventions
Intervention1: Radiation therapy: Radiation therapy 6 fractions per week as opposed to conventionally used 5 fractions per week with weekly Cisplatin at 40mg/sq m in both arms
Control Intervention1: C
Sponsors
All India Institute of Medical Sciences, Bathinda
Eligibility
Inclusion criteria
Inclusion criteria: Biopsy proven squamous cell carcinoma of head and neck. Patients who did not receive any prior management for the malignancy like surgery, radiotherapy or chemotherapy. Patients having malignancy in nasopharynx, oropharynx, hypopharynx and larynx amongst the subsites of head and neck. Patients with malignancy of aforementioned sites of Stage II, III, IV A and IV B Patients performance status should be less than or equal to 2 according to ECOG. Patients who are willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients less than 18yrs of age or more than equal to 70 years of age Patients having malignancy in lips, oral cavity, nasal cavities and paranasal sinuses. Patients who received prior management in the form of surgery, radiation or chemotherapy ECOG score more than 2 Patients with metastatic disease Patients with deranged renal function Patients not willing to give written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the locoregional control rates in both the arms.Timepoint: To compare the locoregional control rates in both the arms at the end of 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the disease-free survival rates in each arm of the study. 2. To assess and compare toxicities as well as compliance in both the arms.Timepoint: both at 6 months | — |
Countries
India
Contacts
Public ContactSneha Bose
All India Instituteof Medical Sciences, Bathinda
Outcome results
None listed