Comparing Two Methods to Wake Patients Faster After Lumbar Spine Surgery

A Comparative Evaluation of Half Dose Sugammadex (2mg/kg) Combined with Neostigmine to full Dose Sugammadex (4mg/kg) for Reversal of Deep Neuromuscular Blockade in Elective Lumbar Spinal Surgery: A Randomised Double-Blind Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101372

Enrollment

102

Registered

2026-01-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M968- Other intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified

Interventions

Intervention1: Inj Sugammadex and Inj Neostigmine versus Inj Sugammadex: Inj Sugammadex (2ml/kg) with Inj Neostigmine (0.05mg/kg) versus Inj Sugammadex (4mg/kg) Control Intervention1: Inj Sugammadex:

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status grade I,II,III Patient Scheduled for elective spine surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Patient refusal Patient with any neuromuscular disorder or renal dysfunction History of malignant hyperthermia History of general anaesthesia exposure in the 7 days preceding the surgery History of known allergy to any drugs used in the study Pregnant and lactating mothers

Design outcomes

Primary

Measure	Time frame
To compare time from reversal administration to 90% of recovery of TOF ratio after vecuronium induced deep neuromuscular blockade (time of extubation)Timepoint: Upto 10 minutes	—

Secondary

Measure	Time frame
1. Time to spontaneous breathing 2. Time to respond to verbal commands 3. Haemodynamic changes after reversal 4. Total duration of anaesthesia & surgery 5. Residual paralysis 6. Side effects/complications, if any Timepoint: It will be measured at these intervals, baseline (before study drug is given), at 0 min (after study drug is given), at 1 min, at 2 min, at 3 min, at 4 min, at 5 min, at 6min, at 7min, at 8min, at 9 min, at 10 min, at 15min, at 20 min, at 25 min, at 30 min	—

Measure

Time frame

1. Time to spontaneous breathing 2. Time to respond to verbal commands 3. Haemodynamic changes after reversal 4. Total duration of anaesthesia & surgery 5. Residual paralysis 6. Side effects/complications, if any Timepoint: It will be measured at these intervals, baseline (before study drug is given), at 0 min (after study drug is given), at 1 min, at 2 min, at 3 min, at 4 min, at 5 min, at 6min, at 7min, at 8min, at 9 min, at 10 min, at 15min, at 20 min, at 25 min, at 30 min

—

Countries

India

Contacts

Public ContactDr. Usha Rani

RNT Medical College

devendraabaes@yahoo.in9829623028

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026