A randomized open labelled comparative clinical study on the efficacy of Virechana Karma in comparison to Lekhana Basti in class I and II Obesity with focus on role of gut microbiota.

A randomized open labelled comparative clinical study on the efficacy of Virechana Karma in comparison to Lekhana Basti in class I and II Obesity with focus on role of gut microbiota. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101369

Enrollment

Registered

2026-01-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E660- Obesity due to excess calories

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Subjects between the age group of 21 - 60 years irrespective of gender, religion, occupation and socio-economic status. Subjects fit for Virechana Karma and Lekhana Basti. Subjects with BMI of less than or equal to 30 kg per m2 to 39.9 kg per m2 Subjects who are willing to give a written consent for the treatment.

Exclusion criteria

Exclusion criteria: Subjects below 21 years and above 60 years of age. Subjects unfit for Virechana Karma and Lekhana Basti. Pregnant and lactating women. Patients with anal pathology which preclude per rectal drug administration viz. fissure, fistula etc., Individuals with secondary obesity due to hormonal imbalance. Patients suffering from uncontrolled diabetes mellitus, uncontrolled hypertension, cardiovascular diseases and other chronic diseases or autoimmune diseases and who are dependent on steroids will be excluded.

Design outcomes

Primary

Measure	Time frame
Generation of evidence to show that either or both Virechana karma and Lekhana Basti would provide similar results by demonstrating statistically significant decreases in obesity classification and rectifying gut microbe dysbiosis leading to improvements in metabolic efficiency using 16 S rRNA V3V4 Metagenomics Analysis. One of the two methods would be superior to the other. Timepoint: Patients will be evaluated before starting the treatment, after completion of treatment and during follow up visit after completion of Parihara Kala. For Virechana- 0th day,12-17th day depending upon number of days of Snehapana. For Basti- 0th day and 12th day.	—

Measure

Time frame

Generation of evidence to show that either or both Virechana karma and Lekhana Basti would provide similar results by demonstrating statistically significant decreases in obesity classification and rectifying gut microbe dysbiosis leading to improvements in metabolic efficiency using 16 S rRNA V3V4 Metagenomics Analysis. One of the two methods would be superior to the other. Timepoint: Patients will be evaluated before starting the treatment, after completion of treatment and during follow up visit after completion of Parihara Kala. For Virechana- 0th day,12-17th day depending upon number of days of Snehapana. For Basti- 0th day and 12th day.

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Secondary

Measure	Time frame
Generation of in-depth analysed data on the different aspects of Virechana Karma, Lekhana Basti, obesity and Gut microbiota influence on obesity. Observing positive changes in stress levels, mood, and sleep patterns etc. contributing to improved quality of life by gut microbiota modulation. Timepoint: Patients will be evaluated before starting the treatment, after completion of treatment and during follow up visit after completion of Parihara Kala.	—

Measure

Time frame

Generation of in-depth analysed data on the different aspects of Virechana Karma, Lekhana Basti, obesity and Gut microbiota influence on obesity. Observing positive changes in stress levels, mood, and sleep patterns etc. contributing to improved quality of life by gut microbiota modulation. Timepoint: Patients will be evaluated before starting the treatment, after completion of treatment and during follow up visit after completion of Parihara Kala.

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Countries

India

Contacts

Public ContactDr Madhushree H S

Sri Sri College of Ayurvedic Science and Research

drmadhushreehs@rediffmail.com9916058006

Outcome results