Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Propofol target-controlled infusion using the Marsh pharmacokinetic mode: Propofol will be administered for induction of general anaesthesia using a target-controlled infusion (TCI) pum
Sponsors
Dr. VIKRAM SHILIGE
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged between eighteen and sixty years Patients with American Society of Anesthesiologists physical status one or two Patients scheduled for elective non cardiac surgery under general anaesthesia Patients with body mass index between eighteen point five and thirty five kilograms per square metre Patients providing written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Patients with American Society of Anesthesiologists physical status three or higher Patients with known cardiovascular instability, such as cardiac rhythm disturbances, uncontrolled high blood pressure, or heart failure Patients with a history of difficult airway or those requiring rapid sequence induction Patients who have received central nervous system depressants or sedative medications within twenty four hours prior to surgery Patients with known allergy or hypersensitivity to propofol or related drugs Pregnant or breastfeeding women Patients with severe liver or kidney impairment Patients with neurological or psychiatric illness Patients who are unable to understand or cooperate with the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage decrease in mean arterial blood pressure (MAP) during induction of general anaesthesia within the first ten minutes following endotracheal intubation.Timepoint: Baseline (prior to induction of anaesthesia) and at 1-minute intervals for 10 minutes following endotracheal intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Total dose of propofol administered during induction, normalised for body weight Timepoint: NIL;Time taken to achieve induction of anaesthesia, defined as attainment of BIS value of 40Timepoint: NIL;Predicted effect-site concentration of propofol at the time of inductionTimepoint: NIL;Requirement of vasopressor support during induction of anaesthesiaTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr VENKATESH S
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH
Outcome results
None listed