A Study on the Effect of Cold Saline Irrigation on Pain After Root Canal Treatment

Effect of Cryotherapy on Postoperative Pain Following Root Canal Treatment with Continuous Chelation: A Randomized Controlled Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101278

Enrollment

Registered

2026-01-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Cryotherapy Group: Continuous Chelation + Cold Irrigation: Root canal treatment performed using a continuous chelation irrigation protocol with 3% sodium hypochlorite combined with 9% e

HEDP)during instrumentation. Intracanal cryotherapy is applied as the final irrigation using 10 mL of sterile normal saline cooled to 2.5 C, delivered slowly over 5 minutes. Control Intervention1: Co

HEDP) during instrumentation. Final irrigation is performed using 10 mL of sterile normal saline at room temperature, delivered slowly over 5 minutes, without intracanal cryotherapy.

Eligibility

Inclusion criteria

Inclusion criteria: Patients presenting with maxillary or mandibular molars diagnosed with symptomatic irreversible pulpitis or symptomatic apical periodontitis, having a baseline Visual Analog Scale pain score between eight and ten, and willing to provide written informed consent and comply with the follow up schedule.

Exclusion criteria

Exclusion criteria: Patients presenting with internal or external resorption, vertical root fracture, retreatment cases, open apices, advanced periodontal disease, immunocompromised status, or a history of chronic pain medication, as well as pregnant or lactating women, will be excluded.

Design outcomes

Primary

Measure	Time frame
Postoperative pain intensity using visual analog scale (VAS) at 6 hours, 12hours, 24 hours, 48 hours and 7 days after the first session of root canal treatment.Timepoint: Postoperative pain intensity using visual analog scale (VAS) at 6 hours, 12hours, 24 hours, 48 hours and 7 days after the first session of root canal treatment.	—

Secondary

Measure	Time frame
To compare analgesic intake as in control & intervention groups.Timepoint: 6 hours, 12hours, 24 hours, 48 hours & 7 days after the first session of root canal treatment.	—

Countries

India

Contacts

Public ContactDr Rudra Deo Kumar

AIIMS,Patna

rudraadhir@gmail.com9990542866

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026