Effects of two throat-numbing interventions (lozenge vs spray) on heart rate and blood pressure in participants undergoing anesthesia

Comparison of changes in hemodynamics with use of lignocaine lozenges and lignocaine spray preoperatively in patients scheduled for general anaesthesia with supraglottic airway - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101277

Enrollment

130

Registered

2026-01-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: K353- Acute appendicitis with localizedperitonitis Health Condition 3: H499- Unspecified paralytic strabismus Health Condition 4: K460- Unspecified abdominal hernia withobstruction, without gangrene Health Condition 5: D493- Neoplasm of unspecified behavior of breast

Interventions

Intervention1: Lignocaine Lozenges: 200mg of Lignocaine lozenges 15 minutes prior to induction. Control Intervention1: Lignocaine spray via atomizer: 10ml of Lignocaine spray(2%) via atomizer 15 minut

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients in age group of 18-60 years 2. American Society of Anaesthesiologists (ASA) Status I and II 3. Patients undergoing elective surgery requiring general anaesthesia with laryngeal mask airway not requiring any other laryngeal or pharyngeal intervention.

Exclusion criteria

Exclusion criteria: 1. Patients allergic to lignocaine hydrochloride 2. Patients with difficult airway with Airway difficulty score more than 8 3. Morbid obesity BMI more than 35 kg per meter square 4. Known airway pathology 5. Oropharyngeal surgeries 6. Surgery duration more than 3 hours 7. Patients at increased risk of aspiration like GERD, peptic ulcer 8. Previous upper gastrointestinal surgery 9. Known or anticipated difficult tracheal intubation or facemask ventilation 10. Coagulopathy or history of anticoagulant use 11. Cervical spine injury 12. Pregnant Patients

Design outcomes

Primary

Measure	Time frame
To compare the changes in haemodynamics between the two groups of patients after BlockBusterTM LMA insertionTimepoint: Baseline Immediately after intervention 1 minute after intervention 2 minutes after intervention 3 minutes after intervention 5 minutes after intervention 10 minutes after intervention	—

Secondary

Measure	Time frame
To assess the patients satisfaction with lignocaine administration techniqueTimepoint: Baseline Immediately after intervention 1 minute after intervention 2 minutes after intervention 3 minutes after intervention 5 minutes after intervention 10 minutes after intervention;2. To study the adverse effects, if any such as coughing, gagging or sore throat. Timepoint: Baseline Immediately after intervention 1 minute after intervention 2 minutes after intervention 3 minutes after intervention 5 minutes after intervention 10 minutes after intervention	—

Measure

Time frame

To assess the patients satisfaction with lignocaine administration techniqueTimepoint: Baseline Immediately after intervention 1 minute after intervention 2 minutes after intervention 3 minutes after intervention 5 minutes after intervention 10 minutes after intervention;2. To study the adverse effects, if any such as coughing, gagging or sore throat. Timepoint: Baseline Immediately after intervention 1 minute after intervention 2 minutes after intervention 3 minutes after intervention 5 minutes after intervention 10 minutes after intervention

—

Countries

India

Contacts

Public ContactParth Nijhawan

Government Medical College and Hospital, Chandigarh

manpreetdawar@gmail.com9646121503

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026