Comparing the Effectiveness of Adrenaline, Clonidine, and Dexmedetomidine in Enhancing Local Anesthesia for Orthodontic Extractions Using the Infraorbital Block.

Comparing the Effectiveness of Adrenaline, Clonidine, and Dexmedetomidine in Enhancing Local Anesthesia for Orthodontic Extractions Using the Infraorbital Block: A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101174

Enrollment

Registered

2026-01-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 2% Lignocaine Hydrochloride with 15 microgram / ml Clonidine: Clonidine is an alpha-2 adrenergic agonist that has shown to improve local anaesthesia by affecting the sympathetic nervous

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient requiring extraction of Maxillary premolar. 2. Patients over age of 15 years, both male and female will be included in this study. 3. Systemically healthy patients. 4.Co-operative, motivated and hygiene conscious patients.

Exclusion criteria

Exclusion criteria: 1) Pregnant or lactating females. 2) Patient with periapical infection in maxillary premolars. 3) Allergy to any local anaesthetic agent and anti-inflammatory drugs. 4) Patients with high-risk systemic diseases. 5) Those who deny for consent.

Design outcomes

Primary

Measure	Time frame
The outcomes of this study will include the onset time, duration of anaesthesia, pain perception during the orthodontic extraction procedure, postoperative pain, analgesic consumption, patient satisfaction, and any adverse effects, to evaluate the efficacy and safety of adrenaline, clonidine, and dexmedetomidine as adjuvants to lignocaine in infraorbital nerve blocks.Timepoint: Outcome variables were assessed at predetermined time points, including onset of anaesthesia (30 seconds to 5 minutes post-block), duration of anaesthesia (until return of sensation), intraoperative pain during extraction, postoperative pain at 1, 2, 4, 6, 12, and 24 hours, analgesic consumption within 24 hours, patient satisfaction at 24 hours, and adverse effects monitored immediately, within 2 hours, and at 24 hours post-procedure.	—

Measure

Time frame

The outcomes of this study will include the onset time, duration of anaesthesia, pain perception during the orthodontic extraction procedure, postoperative pain, analgesic consumption, patient satisfaction, and any adverse effects, to evaluate the efficacy and safety of adrenaline, clonidine, and dexmedetomidine as adjuvants to lignocaine in infraorbital nerve blocks.Timepoint: Outcome variables were assessed at predetermined time points, including onset of anaesthesia (30 seconds to 5 minutes post-block), duration of anaesthesia (until return of sensation), intraoperative pain during extraction, postoperative pain at 1, 2, 4, 6, 12, and 24 hours, analgesic consumption within 24 hours, patient satisfaction at 24 hours, and adverse effects monitored immediately, within 2 hours, and at 24 hours post-procedure.

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Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr. Vrinda Kolte

Ranjeet Deshmukh Dental college and Research centre

drvrindkolte@gmail.com9822366938

Outcome results