A study comparing two medicines (dexmedetomidine and dexamethasone) added to a local anaesthetic (bupivacaine) for pain relief in patients undergoing lower back spine surgery.

Comparison of dexmedetomidine and dexamethasone as adjuvant to 0.25 percent Bupivacaine in erector spinae plane block for pateints undergoing posterior lumbar spine fixation surgery - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101161

Enrollment

Registered

2026-01-14

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Comparison of Dexmedetomidine and dexamethasone as adjuvant to 0.25%bupivacaine in erector spinae plane block for patients undergoing posterior lumbar spine fixation surgery: Patie

Eligibility

Inclusion criteria

Inclusion criteria: Patient posted for elective posterior lumbar spine surgery needing general anaesthesia Patients of all genders Patient aged between 18-65 years Patient with American Society of anaesthesiologists (ASA) Class I and II

Exclusion criteria

Exclusion criteria: BMI more then 35 Patient with newly diagnosed coagulopathy Patient with history of drug allergy More then one attempt at ESP block Inability to provide written consent

Design outcomes

Primary

Measure	Time frame
To compare the duration of post operative analgesia ,post operative opioid consumption ,amount of rescue analgesia ,post surgical stay ,post operatove nausea vomitingTimepoint: To compare the hemodynamics like SBP DBP ,MAP SPO2 Heart Rate and pain score at 0 /2/6/12/24 hrs post operatively	—

Secondary

Measure	Time frame
To compare the Postoperative opioid consumption, amount of rescue analgesia use, post-surgical hospital stay and (PONV) postoperative nausea and vomiting To observe adverse effect related to study drug if any Timepoint:	—

Countries

India

Contacts

Public ContactDr Shubham Khandelwal

Mahatma Gandhi Medical College and Hospital

Shubham.kh29@gmail.com9799052551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026