Health Condition 1: F40-F48- Anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders Health Condition 2: F01-F99- Mental, Behavioral and Neurodevelopmental disorders Health Condition 3: F30-F39- Mood [affective] disorders Health Condition 4: F20-F29- Schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Vaishnav Sethumadhavan
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosis of a major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depressive disorder) as per ICD-11 or DSM-5 criteria by a consultant psychiatrist Drug-na ve or free of psychiatric medication for at least 12 weeks before baseline sample collection. Willingness and ability to comply with study procedures and follow-up schedule and have provided written informed consent.
Exclusion criteria
Exclusion criteria: Presence of acute or chronic inflammatory, infectious, or autoimmune diseases (e.g., TB, SLE, rheumatoid arthritis). Use of anti-inflammatory medications (e.g., NSAIDs, corticosteroids) within the past 2 weeks. Pregnant or lactating women. History of immunosuppressive therapy in the past 6 months Refusal to provide blood samples or inability to complete follow-up assessments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyze the pattern and trajectory of inflammatory biomarker like NLR,LMR,PLR,SII,SIRI and AISI at baseline and over the 8-week treatment period.Timepoint: Baseline 2 weeks on treatment 4 weeks on treatment 6 weeks on treatment 8 weeks on treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the association between changes in biomarker levels and changes in clinical symptom severity over time. Timepoint: Baseline 2 weeks 4 weeks 6 weeks 8 weeks | — |
Countries
India
Contacts
Public ContactVaishnav Sethumadhavan
Vinayaka Missions Kirupananda Variyar Medical College Hospital
Outcome results
None listed