Comparison of different local anesthetic combinations for pain control during inferior alveolar nerve block

Comparative evaluatin of effectiveness of 2 percent Lignocaine HCL,2 percent Lignocaine HCL with 0.2 ml 10 percent Magnesium Sulfate, and 2 percent Lignocaine HCL with 1 is to 200,000 Adrenaline & 0.2 ml 10 percent Magnesium Sulfate in Inferior Alveolar Nerve - A Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/101081

Enrollment

Registered

2026-01-14

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K038- Other specified diseases of hard tissues of teeth

Interventions

Intervention1: Magnesium sulphate as an adjunct to local anesthetic: Administration of magnesium sulphate added to local anesthetic solution for inferior alveolar nerve block in patients undergoing ma

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients reporting to OMFS OPD for extraction of permanent mandibular teeth. 2 Patients of 18-60 years of age of either gender.

Exclusion criteria

Exclusion criteria: 1 Patients who are allergic to local anaesthetics 2 Patients who are non-compliant with post operative instructions . 3 Patient not willing to give informed consent.

Design outcomes

Primary

Measure	Time frame
Faster onset of anesthesiaTimepoint: Onset is measured after injecting anesthesia to first subjective numbness and objective signs of anesthesia within same visit on the same day	—

Secondary

Measure	Time frame
Prolonged duration of anesthesia & reduced pain during extraction procedureTimepoint: Duration of anesthesia is measured from onset of anesthesia to return of normal sensation assessed in minutes within same clinical visit on the same day & pain is measured using VAS score during extraction procedure within same clinical visit on the same day	—

Countries

India

Contacts

Public ContactDr Sandeep Khandaitkar

Ranjeet Deshmukh Dental College and Research Centre

Khandaitkarsandeep@gmail.com9766992263

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026