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A clinical study comparing two procedures for treating alopecia areata microneedling with tacrolimus and platelet rich plasma therapy

COMPARATIVE STUDY OF 0.1 PERCENT TACROLIMUS OINTMENT WITH MICRONEEDLING VS PLATELET RICH PLASMA IN THE TREATMENT OF ALOPECIA AREATA - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/101024
Enrollment
62
Registered
2026-01-14
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L639- Alopecia areata, unspecified

Interventions

Intervention1: platelet rich plasma: After cleaning the venipuncture site with betadine 20 ml of blood will be drawn from the antecubital vein under aseptic precautions using a 21G needle into ACD A v

Sponsors

Dr Baba Saheb Ambedkar Hospital and Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Clinically diagnosed cases of alopecia areata of scalp aged 18 to 60 years with less than 25 percentage scalp involvement. 2. Patients with 1 to 5 patches and SALT score less than 30.

Exclusion criteria

Exclusion criteria: 1.Patients with alopecia totalis, alopecia universalis or Ophiasis. 2.Patients with history of thromboembolism, bleeding disorders, abnormal coagulogram, keloidal tendency etc. 3.Pregnant or lactating female. 4.Patient with any active skin infection at the site of hair loss. 5.Patient who has taken topical or intralesional treatment within the last 1 month and oral treatment within the last 3 months for alopecia. 6.Patient with history of allergy to tacrolimus in past

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of 0.1 percent Tacrolimus Ointment with Microneedling vs platelet rich plasma given 3 weekly for 4 doses in the treatment of localized alopecia areata of the scalp (aged 18-60 years) as assessed by mean SALT scoring at 3,6 ,9 and 12 weeks follow upTimepoint: baseline, 3 weeks , 6 weeks ,9 weeks and 12 weeks—

Secondary

MeasureTime frame
1. To compare the efficacy as per Hair Regrowth Grade Scale (HRG) at 3, 6 ,9 & 12 weeks between two groups. 2. To compare VAS for pain due to intralesional PRP & microneedling between the two groups. 3. To compare the patient satisfaction score between two groups. 4. To compare the side effect profile between two groups. 5. To compare relapse rate at 18 & 24 weeks in both groups Timepoint: basline,3 week, 6 week, 9 week,12 week & 24 week.—

Countries

India

Contacts

Public ContactRidhika Vardhan

Dr. Baba saheb ambedkar hospital and medical college

drViveksagar_sagar@yahoo.com9210338647

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026